Patrick Mahomes, a three-time Super Bowl MVP, continued his dominance over the San Francisco 49ers, improving his record to 5-0 against them after a 28-18 win. He averages 302.0 passing yards per game against the franchise, showcasing his prowess.

However, tensions boiled over during the game when 49ers defensive tackle Maliek Collins delivered a throat punch to Mahomes, an incident that went unpenalized despite the presence of the head official nearby. This moment highlights the ongoing debate about officiating in the NFL, especially regarding Mahomes, who is often perceived as receiving preferential treatment.

Despite the victory, Mahomes faced challenges, extending his career-worst streak of turnovers with multiple interceptions in this game, underscoring the unpredictable nature of the league.