Isaac Yiadom missed practice due to a pelvis injury, contributing to the 49ers' growing list of sidelined players as they prepare for their final game of the season.

Isaac Yiadom is set to face a challenging matchup against Bills' Amari Cooper, as he steps in to cover a key receiver for Buffalo. With Keon Coleman recovering from injury, Cooper is expected to be one of the healthiest options on the perimeter. Yiadom will need to perform well against a Bills offense that has been potent, particularly with Allen targeting his receivers effectively. The 49ers' secondary, already dealing with injuries, could be vulnerable, making Yiadom's performance critical in this high-stakes game.

Isaac Yiadom has an advanced coverage grade of 1.805, placing him in the 75.02 percentile among cornerbacks. This performance reflects a solid level of play, contributing to the overall defensive efforts of the 49ers.

Isaac Yiadom was replaced by rookie Renardo Green in nickel situations, marking a shift in the 49ers' defensive strategy. This change has contributed to the team's improved ability to match up in man coverage, enhancing their overall defensive performance.

Isaac Yiadom of the San Francisco 49ers has an advanced coverage grade of 2.5, placing him in the 82.04 percentile among cornerbacks. This ranking reflects his performance through the first seven weeks of the season, indicating a solid level of effectiveness in coverage.